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If HG continued past mid-pregnancy, did you experience complications during delivery related to your poor health such as a strained ligaments/joints, pelvic floor damage, prolonged or weak pushing, fainting, low blood pressure, low pain tolerance, forceps/assisted delivery, broken bones, nerve damage, low amniotic fluid, fetal problems due to difficult delivery, etc.?


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Current Research Opportunities

HER Foundation and University of California at Los Angeles Collaboration

Current Study: Genetics of Hyperemesis Gravidarum (HG)


Women WHO ARE CURRENTLY PREGNANT may contact Dr. Marlena Fejzo to join our NEW genetic study if you are willing to have a few blood draws in your home.

This study is designed to identify individuals affected with HG, to study epidemiologic factors via an online survey, to collect DNA samples at no cost or travel for you, and to search for genes and risk factors that may be potentially associated with this condition.

All women may now JOIN OUR HG DATABASE to allow study of HG experiences in addition to pre and post pregnancy issues. Enter study ID number 0 in your survey at this link: https://www.helpher.org/HER-Research/2007-Genetics/

Identification of genes and risk factors that contribute to HG will lead to a better understanding of the causes of severe nausea and vomiting of pregnancy, and should be a first step toward the development of more effective treatments or a cure for this devastating disease. To learn more about why Marlena is devoted to finding the cause of HG and information about participating in the study watch Marlena's youtube.com video here.

    • NUTRITION SURVEY- Women currently pregnant are asked to take this nutrition study as often as daily or whenever they receive nutritional treatments or experience a significant change in symptoms.
    • HG SEVERITY INDEX - Support our efforts to validate a NEW clinical tool for clinicians and mothers to evaluate the severity of their HG symptoms. While most scoring tools just assess the frequency of nausea and vomiting, this tool looks at the many factors that exemplify HG including how much you can eat/drink and how hard it is for you to function. If you are currently pregnant with HG, please click this link or scan the QR code to the right with your mobile device and fill out our brief survey. You can return and fill it out as your symptoms change. If you are participating in the above study, note your ID number for this survey if possible. A PDF printable form is also available. The final version will be available soon as it is being validated.

Other HER Foundation Surveys and Polls

Although hyperemesis gravidarum (HG) affects thousands of women annually, few research studies are published annually in comparison to other disorders. We collaborate with experts on research related to HG, as well as conduct semi-annual, online surveys and polls to further our understanding of HG and its treatment. Our Internet research allows us to capture data from around the globe on much larger numbers of participants. Most studies done on HG have less than 200 participants, are not controlled or randomized, and/or may not have enough evidence to support conclusions. Our studies often have over 1000 participants with HG, and we are able work with international experts on HG.

In short, too often HG studies do not meet current research standards. Thus, we aim to conduct and fund research that accurately defines the incidence, outcomes and proactive management of HG to help women get the care they and their unborn child need to survive. We accept donations to sponsor research grants.


Other HG Research Opportunities


Motherisk conducts studies to investigate the safety and efficacy of medications during pregnancy. If you are currently pregnant and would like to participate in their studies, see their website or call their toll free NVP Helpline at 1-800-436-8477 to enroll in a study. Participation usually involves brief phone interviews, that are strictly confidential. Review Motherisk's Current Studies

Governmental Studies (US)

Pregnancy Registry (FDA/Office of Women's Health) If you are pregnant and currently taking medicine — or have been exposed to a medicine during your pregnancy — you may be able to participate and help in the collection of needed information. This web site provides a list of pregnancy registries that are seeking participants.

ClinicalTrials.gov is a service of the National Institutes of Health Developed by the National Library of Medicine. You can search for research studies in which to participate as well as investigate the findings of medical research.

Updated on: Jul. 11, 2019

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