What should I try now?? Need med advice from the experts

A place to discuss all things treatment-related. Medications, IVs, midlines, PICC lines, NG tubes, sub-q pumps, home health care, etc. Also includes alternative and homeopathic remedies including NAET, vitamins, liver detoxing, and more for active HG and TTC preparation.

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What should I try now?? Need med advice from the experts

Postby tilly2321 » Feb 22, 2005 9:12 pm

Hi all,
I am taking diclectin (Live in Us, but midwife presribed it for me and got it through online)I feel like I am going to barf and nothing sounds good to me at all. I don't know what else to try. I have a two year old and need to function. Today, was a bad day and I am hoping that it will be better tomorrow. I was doing really well emotionally, but looking at the calendar can get depressing. Anyhow, should I try meclizine next? Zofran? My symptoms are motion related nausea that is constant and major food aversions.
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Postby HGx3 » Feb 22, 2005 11:44 pm

I copied and pasted this here for you to read, it is very informative. Hope it helps!!!!!

Welcome! This is a post containing information about Zofran/B6/Unisom and a bit more. If you are new to this site, and in the midst of HG, this post is for you, although everyone should be familiar w/ it to know it's here. It was originally written to a new HGer a while back, and revised it a bit after suggestions that it be used here. It's written from my perspective directly to you.

Zofran is available taken by mouth and swallowed as an oral tablet in 4 or 8 mgs. Zofran is available ODT - which means it is sublingual, and dissolves in your mouth w/o the need of any liquid to swallow it. It is immediately absorbed into the blood stream, 4 and 8 mgs. Zofran can be injected into your IV or PICC line - wish I would have asked for this one in the hospital! Zofran I think is also available in a subcutaneous pump. The more direct the route between med and your blood stream, the more effective the drug tends to be. In order of effectiveness from least to greatest: Oral, ODT, pump, IV. The biggest adverse reaction to Zofran here is constipation, and several highly suspect it added to their weakness, although the weakness could have been recovery from repeat HG pgs..

I took my Zofran around the clock every 6 hours, so when I was on 16 mgs a day, I was setting an alarm at night to wake up, swallow it, go to the bathroom, eat a cracker so my tummy wasn't empty (graham cracker) and then would go back to sleep. Some gals just sleep through the night, and then take it when they get up. I was too afraid to try that, and so I took it every 6 hours - like clockwork. It depends on what works better for you, go w/ your gut feeling - it's usually right - even if it's against what we think is best (that's a generality that's important to remember - we have lots of opinions, but it's just to help you know what your options are, and we will support your decisions).

The highest doseage of Unisom is 3 Unisom/day = 75 mgs. There are two types of Unisom on the market. One is the sleep tabs - containing Doxcilimine Succinate. This is the one you DO want. The other is a sleep gel, and contains a different ingredient for sleep aid, and we don't use it. Now, it is a sleep aid, and some are made drowsy with it, but not nearly so much as the Phenergan as a comparison. I haven't heard it compared to the Tigan, so am no help there. I do know, however, that if you break it up into smaller pieces (even quarters) that the sleepy effect is greatly reduced. I was on the B6/Unisom combination for both my pgs, and after a little while, I can remember being disappointed that it didn't help me sleep better! I have never been on more than 2/day, and the 3/day is info from 2002 from Motherisk (a nausea and vomiting support call center in Canada, and is available to the US - www.motherisk.org <http://www.motherisk.org> look up morning sickness).

Ok, B6. Prolonged useage of B6 at high doses (I think the study was 1,000 mgs a day) can lead to nerve damage. Motherisk recommends 150 mgs per day. 200 at the height of HG for a month or two is not considered prolonged useage, and is safe, and I would do it if 200 worked better for me than 150. I'd feel pretty uncomfortable ever going over 200 mgs/day. There are different ways B6 is available. Firstly, it's available over the counter at any grocery or drug store in a tablet (yes, another pill to swallow!). I try to remember to take B6 to lessen my PMS symptoms, and mine are 100 mgs, and I know that you can get them smaller mgs than that. For the $, higher mgs is a much better deal, but don't take the full 100 at a time. B6 must be paired with an enzyme in order to be available for use within the body, and unpaired B6 is just wasted in the urine, so do not take more than 25-50 mgs at a time, and stretch them out so they are more effectively absorbed. The oral tablets can be hard to split, and a pill splitter is worth it's weight in gold. B6 is also available in a sublingual form, which means that it dissolves in your mouth w/o having to swallow it, and is absorbed into your blood stream - no water needed. Sublingual is already paired with the enzyme. Sublingual B6 is available in 25 mgs which also gives you more flexibility in being able to take it as needed. I've heard that the peppermint flavor is preferrable over the orange, and it needs to be special ordered by a health foods store for you, or a vitamin store, or can be purchased on-line, and if you need help finding it on-line, I know where, just ask, and I'll dig up. I also know that Motherisk is doing a study about the comparison of the efficacy of sublingual vs. the pill B6 form. Ok, the 3rd form of B6 is referred to as Pyridoxine (B6) Injections. They sting, they hurt, they build scar tissue, but not having any clue about the sublingual B6 when I was pg, I had injections w/ both of mine, and it kept me out of the hospital, and were that last little thing that kept me from going over the edge (in addition to the Phenergan or Zofron/Unisom I was already on). I wonder if sublingual is as effective as the injected, or nearly so, but haven't had that one answered. I do know personally that 100mgs injected was more effective than 200 taken orally. B6 follows the same absorption rules as other meds. Oral least effective, sublingual MUCH MORE effective w/ B6, and injected IM (intramuscularly) is even better. B6/Unisom is more effective taken together, at the same time, but they are individually helpful as well. Some gals do not react well to one or the other, so use them w/o the other.

It seems that for one or two, Zofran did lose it's effectiveness, but we're really unsure if the HG is getting too bad for the Zofran to handle, or if it stops working, or what. Zofran, though, for most of us is a great vomit handler, unfortunately, it leaves nausea behind. The B6/Unisom for most helps w/ the nausea, and isn't enough for the vomiting - that's why combinations seem to work for so many, because they address different HG issues, even if it's a different combination than Zofran/B6/Unisom. For a few, the Zofran handles nausea, and the vomiting needs to be handled differently (like w/ Meclizine) so be aware that the same stuff at the same dose is not equal for all HGers.

A PICC is not your only option. If none of the combinations we suggested work better, than you can certainly try steroids or an NG tube. Steroids are more easily prescribed by a perinatologist, in case you're interested and your Dr. balks. They have been used for other types of pg issues, outside of HG, so we know from research that they are fairly safe. They have been used very successfully in some cases of HG that are not responding to other treatments, and may be a viable option. You can also do an advanced search, and search for steroids here at HER, and all sorts of info will come up, if that isn't enough, let us know, we'll find you more, feel free to ask questions, and to ask for more info.

Now, a PICC for some HGers isn't such a bad thing at all. For me, it's pretty terrifying, but when faced w/ many and repeated pokes for IVs, it looks much more appealing! If you do get into a position of needing constant hydration, it's an option to consider.

NG tubes are something I know more about receantly. Mamalily, one of our moderators had an NG tube that worked quite successfully. If it looks like you're headed towards needing consistent nutrition I'd recommend an NG tube over a PICC line w/ TPN. There are many pros and cons: nearly no risk of infection, keeps your intestines functioning, and doesn't stress out your liver. All pills can be crushed and mixed with water, and the NG tube can end in your small intestine, so you're not vomiting up what goes down. I'll work with Mamalily to get the regimen for placement posted on here at HER.

You know, all Drs. are not all equal when it comes to HG knowledge. Some know more than others, and they have different opinions about treatments, and amounts, etc. The information we offer you is from the patient side of things - the HG sufferer side of things - the things we've learned from sitting down and comparing what worked for one, and didn't for another, and what different Drs. tried, etc. I think most HGers hit a point where they just have to become more proactive about their care, either you'll need to ask more questions, or suggest treatment options, etc. Some Drs. are threatened by this, and some welcome it, and there's only one way to find out, and that's to ask for better treatment, or specific options they haven't suggested. We have had HGers ask for help in locating a new Dr. because of the ignorance of the one they have, or the lack of deceant treatment. We have some gals who are fantastic at helping with this. Hopefully, if you really like your Dr. they will be willing to try some other suggestions. Combinations really are more effective for most it seems, and it just takes some experimentation to figure out if they might work well for you. I wish we could just give you a regimen that works guaranteed for everyone, but we haven't found one yet!

Here at this website, we are surrounded by the best HG info that is available. Kimber is the co-founder of the official HER foundation and this website and has spent years researching HG and gathering the information we now have at our fingertips. Research and read here.

Homeopathy has been used successfully by an HGer in the UK - find her story at www.hyperemesis.org.uk. Kerry had a surprise pg that she was able to successfully manage better than her previous HG experience by using a knowledgeable homeo/naturopath. There is more important homeopath information in our Alternative Treatment forum, or there will be by Aug. 2004.

Feel free to ask for help. There is a lot of information here, and we know you are not feeling even close to your best, or normal. We're here for you, so don't feel like you have to sort through everything to find all the answers - we really will do that for you!

Sending you hugs, and maybe you've found some relief knowing you're not the only one as many others have. We've been there, or we are there now, we know how you feel, and you're not alone anymore.
Huge Hugs,
HG Mom to:
Matthew, 2001
Lauryn, 2002

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