Hi Garrett,
Welcome to the boards, though I'm sorry your wife is so ill that you need to be here.
I personally am on zofran and so far the Dr.s have noted no complications and I find that if I were not on this drug things would be far worse for me. There are many options of treatment, some you can do yourself, others that require a dr. I would suggest trying first off the b6/unisom combo that you will find information on at the top of any trimester folder. Also, I know many women on this site have used zofran and have gone on to deliever happy, healthy babies and have yet to hear of anyone having zofran complications to the baby. This is just what I have noted however, so please contiune your own research.
There is also a large medication section that breaks down most common drugs used in HG and gives a list of benefits as well as risks you could print out and discuss with your medical team. The link is below.
http://www.helpher.org/mothers/treatments/medications.php
I hope this helps you. Good luck, and you're a wonderful man for showing such concern for your family.
Please keep us updated as you are able. And if possible, have your wife come to the boards. We will do our best to cheer her on and support her. If she's too ill, read her some of the posts in the humor sections etc. to give her hope and help take her mind off this horrible suffering if only for a moment.
`hugs`
Amber